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US11208490B2 — Methods for the treatment of thyroid eye disease
Priority Date 2018-03-05
무효화할 청구항을 선택하고 구성요소 텍스트를 편집하세요.
A method of reducing proptosis by at least 2 mm in an eye in a subject with thyroid eye disease (TED) comprising: administering to a subject in need thereof a therapeutically-effective amount of an antibody, or a fragment thereof, that comprises a heavy chain CDR1 of SEQ ID NO:1, a heavy chain CDR2 of SEQ ID…
A method of improving diplopia in a subject with thyroid eye disease comprising administering an antibody that specifically binds and inhibits IGF-IR for a treatment period of at least 24 weeks.
대응 독립항이 무효가 되면 종속항도 함께 무너집니다. 기본으로 모두 포함하되, 특정 종속항만 겨냥하려면 개별 선택하세요.
The method of claim 1, wherein said antibody is administered at about 10 mg/kg as a first dose and about 20 mg/kg in subsequent doses.
The method of claim 2, wherein proptosis is reduced by at least 4 mm.
The method of claim 1, wherein the antibody is administered every three weeks.
The method of claim 4, wherein the antibody is administered for a total of eight infusions.
The method of claim 1, wherein the subject has active thyroid eye disease.
The method of claim 6, wherein the subject has a Clinical Activity Score (CAS) of at least 4.
The method of claim 1, wherein the antibody is teprotumumab.
The method of claim 1, wherein proptosis is reduced at week 24 relative to baseline.
The method of claim 9, wherein the reduction in proptosis is maintained through week 48.
The method of claim 1, wherein the subject is human.
The method of claim 1, wherein the antibody is administered by intravenous infusion.
The method of claim 12, wherein each infusion is administered over about 60 to about 90 minutes.
The method of claim 1, wherein the subject exhibits an improvement in diplopia.
The method of claim 15, wherein diplopia is improved by at least one grade.
The method of claim 15, wherein the antibody is teprotumumab.
The method of claim 15, wherein the subject was previously treated with corticosteroids.
The method of claim 18, wherein the subject did not respond to corticosteroid treatment.
The method of claim 15, wherein the treatment period is at least 48 weeks.
7 elements 기준으로 검색 쿼리 약 17개를 만듭니다.
탐색에 보통 8–15분 걸립니다. 창을 닫아도 계속 진행됩니다.
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예상 소요 약 6분
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